Valcour Lab
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Overview
Advances in HIV anti-retroviral therapies in recent years have allowed for a newly emerging HIV+ population that is aging well into and beyond their 50's and 60's. While research on cognition in younger HIV+ individuals demonstrates a risk for earlier onset of cognitive decline, there is little research on the prevalence and characteristics of HIV associated neurocognitive disorders (HAND) among patients over the age of 60. In addition to shedding light on the impact of HIV infection on cognition and function in this oldest demographic, our HIV+ Over 60 Cohort Study will also provide insight into geriatric syndromes and the predictive ability of some frailty measures on cognition.

This is a longitudinal study which will follow participants annually. Our approach involves annual data collection through neurological exams, neuropsychological and functional testing, geriatric syndromes assessment, laboratory tests, and, on some years, multi-modal brain imaging.

Data collected include:
  • Cognitive and functional assessment
  • Assessment of depressive symptoms and psychiatric comorbidity
  • Medication review
  • Geriatric measures
  • Clinical laboratory measures
  • Neurological Examination
  • Brain imaging

This study is currently closed to enrollment.

Collaborators
  • UCSF Alzheimer's Disease Research Center (ADRC), San Francisco CA
  • UCLA Laboratory of Neuro Imaging (LONI), Los Angeles CA
  • California NeuroAIDS Tissue Network
Study Publications
  • Disrupted Brain Networks in the Aging HIV+ Population. Brain Connectivity 2012
  • Impact of HIV and aging on neuropsychological function. J NeuroVirology 2012
  • The Montreal cognitive assessment to screen for cognitive impairment in HIV patients older than 60 years. JAIDS 2014

Sponsors
  • This study is funded in part by UCSF and by the National Institutes of Health.
Contact
For more information about this study, please contact the study coordinator:
    Shireen Javandel
    Tel: 415-476-1688
    shireen.javandel@ucsf.edu

Image courtesy of Rich Niewiroski Jr

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