Below is a list of our projects currently in progress. A list of publications can be found on the Publications page.
UCSF: MIND Study
The MIND Study is designed to accurately distinguish mild cognitive impairment due to Alzheimer's disease from HIV-associated cognitive impairment among individuals over age 60 by using machine learning for data-driven discovery of imaging and clinical data. Located in San Francisco, this study includes neurological examinations, neuropsychological testing, geriatric syndrome assessment, functional testing, multimodal MRI, lumbar puncture and amyloid PET imaging. For more information, please click here.
The MIND Study is designed to accurately distinguish mild cognitive impairment due to Alzheimer's disease from HIV-associated cognitive impairment among individuals over age 60 by using machine learning for data-driven discovery of imaging and clinical data. Located in San Francisco, this study includes neurological examinations, neuropsychological testing, geriatric syndrome assessment, functional testing, multimodal MRI, lumbar puncture and amyloid PET imaging. For more information, please click here.
UCSF: HIV Over 60 Cohort
UCSF HIV Over 60 Cohort study is designed to understand the basic neurological epidemiology of aging with HIV within a unique cohort of individuals over 60 years of age. Our study is currently enrolling subjects in San Francisco and includes neurological examinations, neuropsychological testing, geriatric syndrome assessment, functional testing for everyday activities and multimodal brain imaging. This work is completed in collaboration with the UCSF Alzheimer's Disease Research Center (ADRC) and the Laboratory of NeuroImaging (LONI) at UCLA. For more information, please click here.
AFRICOS: The African Cohort Study
AFRICOS aims to understand HIV infection in the African context. UCSF is involved in the annual cognitive assessments that will estimate frequency of cognitive impairment and predictors of impairment in the African context. We have particular interest in clarifying potential differences between clades A and D infection as it relates to cognition on reservoirs. For more information, please click here.
SEARCH 010: Long-term Consequences of Treatment During Acute HIV Infection
This study takes place in Thailand, and aims to elucidate the earliest neurological and immunological events that occur with HIV infection, and to characterize the long-term effect of antiretroviral treatment initiated during this acute phase of infection. Subjects are enrolled within the first weeks of HIV infection and followed for up to six years. Full clinical evaluations are conducted, as well as neuropsychological testing and MRI scans. The long-term goals of this study include informing mechanisms s for eradication of the CNS viral reservoir in HIV. For more information, please click here.
SEARCH 013: Characteristics of immunity in gut mucosa, spinal fluid, lymph node and blood of HIV negative Thais and Thais with HIV infection
In order to establish control data to compare immunologic and virologic data with those in SEARCH 010, this study looks at HIV negative subjects and non-acute HIV subjects. This will allow for correct scientific interpretation of changes seen in the immunologic and neurologic compartments in the context of acute HIV infection.
