SEARCH 013: Characteristics of immunity in gut mucosa, spinal fluid, lymph node and blood of HIV negative Thais and Thais with HIV infection
Overview
The Southeast Asia Research Collaboration with Hawaii (SEARCH) operates and collaborates on several neuroAIDS research protocols. SEARCH 013 will serve to recruit and study control subjects to compare to acutely HIV-infected participants in SEARCH 010. The characteristics of immune cells by immunophenotyping and immunohistochemistry in the gut mucosa of HIV-negative and non-acutely HIV-infected adults will be studied.
Participants ages 18 to 50 years old will be recruited in Thailand from the Thai Red Cross Anonymous Clinic, Chulalongkorn University Hospital, and the Early Capture HIV Cohort Study (ECHO). We are looking to have 100 HIV negative subjects and up to 100 subjects with HIV infection.
We are hoping that the control samples recruited in this study will allow for accurate scientific interpretation of immunologic changes seen in acute HIV infection as well as changes seen in the neurologic compartment. This study will also allow acutely HIV infected adults participate in a research study who may not feel up to the intensive follow-up schedule of SEARCH 010. SEARCH 013 captures data through brain magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and diffusion tensor imaging (DTI). Other samples collected for analysis include excisional lymph node biopsies, cerebrospinal fluid (CSF), genital secretions, and colon biopsy.
The Southeast Asia Research Collaboration with Hawaii (SEARCH) operates and collaborates on several neuroAIDS research protocols. SEARCH 013 will serve to recruit and study control subjects to compare to acutely HIV-infected participants in SEARCH 010. The characteristics of immune cells by immunophenotyping and immunohistochemistry in the gut mucosa of HIV-negative and non-acutely HIV-infected adults will be studied.
Participants ages 18 to 50 years old will be recruited in Thailand from the Thai Red Cross Anonymous Clinic, Chulalongkorn University Hospital, and the Early Capture HIV Cohort Study (ECHO). We are looking to have 100 HIV negative subjects and up to 100 subjects with HIV infection.
We are hoping that the control samples recruited in this study will allow for accurate scientific interpretation of immunologic changes seen in acute HIV infection as well as changes seen in the neurologic compartment. This study will also allow acutely HIV infected adults participate in a research study who may not feel up to the intensive follow-up schedule of SEARCH 010. SEARCH 013 captures data through brain magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and diffusion tensor imaging (DTI). Other samples collected for analysis include excisional lymph node biopsies, cerebrospinal fluid (CSF), genital secretions, and colon biopsy.
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Collaborators
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Study Publications
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Sponsor
- US Army MRMC- HJF Cooperative Agreement W81XWH-11-2-0172 Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, MD for study conduct (MIDRP 1C0025-08). The award expires in September 2016 after which the funding will transition to HIV Vaccines Advanced Development 811/812
