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SEARCH 011: The Peripheral Reservoir of HIV DNA in Monocytes is Pivotal to Cognition in HIV

SEARCH 011 Study
Overview
SEARCH 011 aims to understand the role of the circulating monocyte HIV DNA reservoir on brain injury. To investigate the link between levels of HIV DNA and cognition, we are closely monitoring and testing 60 research subject initiating combination antiretroviral therapy for the first time, before and after starting treatment. Our tests include cognitive characterization, neurological examinations, common laboratory testing, brain MRI with spectroscopy, evaluation of cerebrospinal fluid cytokines and virus and the quantification of HIV DNA in peripheral blood mononuclear cells (PBMC) and isolated CD14+ monocytes.  We are exploring correlations between HIV DNA in these peripheral cells and cognition, as well as searching for a biomarker of HIV-associated neurocognitive disorder (HAND).  Infrastructure development within this project allows us to develop normative data for neuropsychological testing and to determine the utility of the International HIV Dementia Scale for Southeast Asia.

Currently, the study is fully enrolled and we have successfully completely baseline, six-month, and one year follow-up assessment on all subjects.

Collaborators
  • SEARCH Thailand, Bangkok
  • Thai Red Cross AIDS Research Center, Bangkok
  • Chulalongkorn University, Bangkok
  • Phramongkutklao Hospital, Bangkok
  • US Armed Forces Research Institute of Medical Sciences, Bangkok
  • Hawaii Center for AIDS at the University of Hawaii, Honolulu HI
  • US Military HIV Research Program, Bethesda MD
  • Harvard School of Public Health, Boston MA
  • Washington University, St. Louis MO
  • University of Missouri, St. Louis MO
Study Publications
  • Development of normative neuropsychological performance in Thailand for the assessment of HIV-associated neurocognitive disorders. J Clin Exp Neuropsych 2012
  • Failure to clear intra-monocyte HIV infection linked to persistent neuropsychological testing impairment after first-line combined antiretroviral therapy. J NeuroVirology 2012
  • HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complications. J Leukocyte Biol 2010
  • Trail Making Test A improves performance characteristics of the International HIV Dementia Scale to identify symptomatic HAND. J NeuroVirology 2013

Sponsors
  • This project is funded by the National Institutes of Neurological Disorders and Stroke (NINDS) R01-NS061696.
Contact
Jennifer Daniels
Research Coordinator
Tel 415-502-7603
[email protected]
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