SEARCH 011: The Peripheral Reservoir of HIV DNA in Monocytes is Pivotal to Cognition in HIV
Overview
SEARCH 011 aims to understand the role of the circulating monocyte HIV DNA reservoir on brain injury. To investigate the link between levels of HIV DNA and cognition, we are closely monitoring and testing 60 research subject initiating combination antiretroviral therapy for the first time, before and after starting treatment. Our tests include cognitive characterization, neurological examinations, common laboratory testing, brain MRI with spectroscopy, evaluation of cerebrospinal fluid cytokines and virus and the quantification of HIV DNA in peripheral blood mononuclear cells (PBMC) and isolated CD14+ monocytes. We are exploring correlations between HIV DNA in these peripheral cells and cognition, as well as searching for a biomarker of HIV-associated neurocognitive disorder (HAND). Infrastructure development within this project allows us to develop normative data for neuropsychological testing and to determine the utility of the International HIV Dementia Scale for Southeast Asia.
Currently, the study is fully enrolled and we have successfully completely baseline, six-month, and one year follow-up assessment on all subjects.
SEARCH 011 aims to understand the role of the circulating monocyte HIV DNA reservoir on brain injury. To investigate the link between levels of HIV DNA and cognition, we are closely monitoring and testing 60 research subject initiating combination antiretroviral therapy for the first time, before and after starting treatment. Our tests include cognitive characterization, neurological examinations, common laboratory testing, brain MRI with spectroscopy, evaluation of cerebrospinal fluid cytokines and virus and the quantification of HIV DNA in peripheral blood mononuclear cells (PBMC) and isolated CD14+ monocytes. We are exploring correlations between HIV DNA in these peripheral cells and cognition, as well as searching for a biomarker of HIV-associated neurocognitive disorder (HAND). Infrastructure development within this project allows us to develop normative data for neuropsychological testing and to determine the utility of the International HIV Dementia Scale for Southeast Asia.
Currently, the study is fully enrolled and we have successfully completely baseline, six-month, and one year follow-up assessment on all subjects.
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